Two novel malyngolide analogues, (${pm}$)-dehydromalyngolide and (${pm}$<TEX>)-isomalyngolide, of (-)-malyngolide antibiotic have been synthesized by application of our previously developed synthetic sequence for the synthesis of (<TEX>${pm}$<TEX>)-malyngolide. Dehydromalyngolide was synthesized from the known lactone (4) in a 55 % overall yield in six steps, while isomalyngolide was synthesized from the readily available keto ester (11) in a 56 % overall yield in four steps.