Endoscopic esophageal sclerotherapy(EES) has been widely accepted for management of bleeding esophageal varices. Authors reviewed CT indings of mediastinal and pleural changes before and after EES for the evaluation of the effect and complication. The mediastinal and pleural changes within 3 days (n=20) after EES were esophageal thickening(80%), esophageal lamination(40%), paraesophageal gas collection 935%), paraesophageal mediastinal effusion 980%), and pleural effusion 950%). After 2 months (n=5), all these findings were disappeared, except for mild residual esophageal thickening. The knowledge of CT findings after EES appeared essential for CT scan images performed in the patients suspected of having severe postprocedural complications and for the differential diagnosis.