A convenient method for the synthesis of indoprofen, which is a potent antiinflammatory agent, w described. Ethyl $alpha$-(4-aminophenyl)propionate was prepared by nitration of ethyl $alpha$-phenylpropionate, followed by reduction. Ethyl $alpha$-[4-(1, 3-dioxo-2-iso-indolinyl)phenyl]propionate was obtained from condensation reaction of phthatic anhydride and ethyl $alpha$-(4-aminophenyl)propionate. Indoprofen was prepared by reduction of ethyl $alpha$-[3-(1, 3-dioxo-2-iso-indolinyl)phenyl]propionate with zinc dust-acetic acid, followed by hydrolysis of the resultant ethyl $alpha$-[4-(1-oxo-2-iso-indolinyl)pheriyl]propionate.