In order to study the anti-stress effect of Bunsimgieum, the changes of plasma catecholamine, aldosterone and cortisol levels were measured. In this study author gave immobilization stress to rats, and got the following results: 1. The contents of NE and EPI control group were $2.67{pm}0.53$, $1.90{pm}0.22;ng/ml$, but in sample group the contents were $1.93{pm}0.67$, $1.15{pm}0.28;ng/ml$. The real significance lies in thet only NE show the difference. 2. The contents of aldosterone in control group were $440.69{pm}37.82;Pg/ml$, but in sample group $174.64{pm}42.41Pg/ml$ of aldosterone was measured. The difference was obvious. 3. The cortisol contents in control group were $0.17{pm}0.03;ug/dl$, but in sample group $0.28{pm}0.03 ;ug/dl$ of cortisol was measured. Base on the results above, it may be concluded that Bunsimgieum is effective to prevent to prevent the changes by stress.