Globus pharyngeus is a common problem comprising between 3% and 4% of new otolaryngology outpatient referrals. We do not understand the etiology of globus exactly and it is remained a disease of exclusion. The treatment of globus pharyngeus is still not established. The aim of this study is to understand the etiologic factors and determine the reliable guide for selecting method of choice of evaluation and improving therapeutic response of globus pharyngeus. A total of 141 patients were investigated by authors. 25 of 141 patients were excluded from the study because they could not satisfy the definition criteria of this study. After detailed Interview and comprehensive physical examinations, all the 116 patients had underwent barium esophagogram, fiberoptic esophagogastroscopy, esophageal manometry and 24-hour pH monitoring. They could follow up for at least 3 months. There were 43 male and 73 female subjects and the mean age was 46.5 year. Esophagogram revealed normal in 94(81%) subjects. 78 patients(67.2%) were normal in esophageal manometry. Gastroesophageal reflux(GERD) was found in 24 cases and borderline GERD was found in 25 cases showing an overall incidence of 42.2% for 24-hour pH monitoring. Especially 44(89.8%) of the 49 patients with proven reflux on 24-hour pH monitoring showed therapeutic response whereas 48(71.6%) of the 67 subjects without reflux showed response.