In order to improve cultivation technique of Codonopsis lanceolata, uniconazol and paclobutrazol were treated periodically with foliar application during differentiation of node. Plant height, width and length of leaves decreased as the concentration of uniconazol and paclobutrazol increased independently of application period. Characteristics of subterranean part of all treatment by uniconazol foliar application did not show any significant difference to control, except when treated at the differentiated stage of 3rd node. But, when uniconazol was treated with the concentration of 10, 100mg $liter^1$, respectively at the differentiated stage of 12th node, fresh weight was increased to approximately 64%, 100% of control, respectively. Control and 10mg $liter^1$ treated at the differented stage of 6th node showed antitumor activity by the P388 cytotoxic screening test. Fresh weight of all treatment by paclobutrazol foliar application was not showed signigicant difference to control, except when treated at the differentiateed stage of 3rd node. But, when paclobutrazol was treated with the concentration of 10mg $liter^1$ at the differentiated stage of 12th node, fresh weight was slightly increased of control. All treatment showed slight antitumor activity by the P388 cytotoxic screening test.