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수용성 약물인 세파클러를 함유하는 젤라틴 마이크로캅셀의 제조 및 약물 방출특성
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  • 수용성 약물인 세파클러를 함유하는 젤라틴 마이크로캅셀의 제조 및 약물 방출특성
  • Preparation of Cefaclor-Containing Gelatin Microcapsules and Their Drug Release Characteristics
저자명
조성완,박종화,박준상,장정수,최영욱,Cho. Seong-Wan,Park. Jong-Hwa,Park. Jun-Sang,Jang. Joung-Soo,Choi. Young-Wook
간행물명
약학회지
권/호정보
1997년|41권 1호|pp.30-37 (8 pages)
발행정보
대한약학회
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정기간행물|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by th e method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50 ${mu}$m. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.