This paper reports a peculiar example of flow-induced vibration in a very large plant and the whole procedure of reducing the vibration. During the operation of flue gas desurfurization unit of the thermal power plant, serious vibration was dtected at all around the plant. The worst vibration was recorded on the heat exchanger surface, which weighed 180 tones, as 17.8 m/$s^2$ in vibration amplitude at 34 Hz. To identify the vibration, frequency analysis on the response vibration as well as on the expected excitation forces and the system resonance was executed. This investigation revealed that the cause of the vibration was vortex shedding from the circular pipes in the heat exchanger. Vortices from the pipes excited acoustic resonance in the heat exchanger room, which, in turn, made the structure vibrate. Through inserting the baffles between the pipes, which had an effect of cutting the acoustic wave at resonance frequency, the vibration was eliminated dramatically.