Multipurpose fisheries base was conceptually designed to establish marine ranching system in the coastal waters around Tongyoung, southern sea of Korea. Fisheries base for marine ranching system has integrated various facilities which were required for the process of spawning, rearing, training, releasing, monitoring and catching functions. This base has five steel piles for supporting upper structure and systems. Four steel piles are surrounded by circular net pen made by steel wire, they have the function of the protection against fouling for pile and scouring for bottom soil as well as secondary rearing and short stocking. We can use the last pile to moor a ship and access to the base. Principal structure with steel piles is designed by optimization technique considering design external forces in the coastal waters of return period of 50 years. Design optimization Problem is formulated for this base. Optimal design of multipurpose fisheries base is numerically investigated by sequential quadratic programming method.