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Textural Characterization of Gel Layer Thickness and Swelling Boundary in a Hydrophilic Compact
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  • Textural Characterization of Gel Layer Thickness and Swelling Boundary in a Hydrophilic Compact
  • Textural Characterization of Gel Layer Thickness and Swelling Boundary in a Hydrophilic Compact
저자명
김현조,레자 파시히,Kim. Hyun-Jo,Fassihi. Reza
간행물명
藥劑學會誌
권/호정보
2001년|31권 1호|pp.13-18 (6 pages)
발행정보
한국약제학회
파일정보
정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

This study was to investigate the relationship between the gel layer thickness and swelling boundary via strength measurements using texture analysis. The novel texture analysis approach was used to examine the dynamics of swelling behavior in a ternary polymeric matrix tablet. The method permitted the characterization of the changes occurring at the peripheral as well as within interior boundary of the swelling during water ingress. The increase in gel strength for pectin, HPMC, and a ternary mixture with gelatin was found to depend on polymer concentration. Therefore, this method is further applicable to characterize the swelling behavior and provide opportunity to differentiate the gel-layer from that of swelling boundary.