In present study a methodology has been developed and applied for the optimum design and performance evaluation of microchannel heat sinks. The optimum design parameters include channel number and fin thickness. For a trial model of 127mm in length, 52.5mm in width, 16mm in height and 2.5mm in base thickness, the optimum channel number and the fin thinckness have been determined to be of 194 and 0.08359mm, respectively in laminar flow region. Performance of the optimally designed microchannel heat sinks has been compared with those having 50% and 150% of the number of channels. The results showed that the 50% and 150% designs increased the pumping power by 200% and 150%, respectively.