An experimental investigation on the flexural fatigue behavior of a RC bridge slab retrofitted with Carbon Fiber Sheet (CFS) is presented. The test slab was almost identical to the slab of a highway viaduct in terms of the amount of reinforcement, quality of concrete and thickness of the slab, which was 18cm. Repeated load corresponding to 3.0, 4.5 or 6.0 times of the design load was applied to the test slab. Normal type and high-elastic modulus type of CFS were used for strengthening. The test slabs were loaded in dry or wet condition. Two different types of an-choring system were adapted. Some of the test slabs were damaged by the repeated load and retrofitted by CFS, then loaded again to see the improvement of the fatigue life. Infrared Thermography was also performed to investigate the debonding condition of CFS. From the test results, Carbon Fiber Sheet can be applied to the RC bridge slabs as a feasible retrofitting material.