In this paper, compact lumped-element low-pass filter structure with two transmission zeros at second and third harmonics is presented. The use of lumped-elements and transmission zeros can provide the advantages of compact size, sharp cutoff and wide stop-band frequency response. The proposed low-pass filter is a modified Chebyshev low-pass filter type and is implemented by the use of low temperature co-fired ceramic (LTCC) technology. This filter has been verified by both simulation and experiment. The simulated and experimental results agree very well.