Various biodegradable polymers (PLLA-PEG-PLLA, PLLA-PPG-PLLA, PLLA-PN-PLLA) were synthesized and their affinities with cells were measured. Cell migration rate was more dependent on the cell density rather than on the characteristics of polymer. PLLA-PN-PLLA film showed formation of cohesive cell structure. The contact angle of this film was almost the same as that of PLLA. However, initial number of cell attachment of PLLA film was 3 to 4 times higher than that of PLLA-PN-PLLA copolymer film.