Recently, the reliability evaluation and analysis are applied for many industrial products, and many products are required to guarantee in quality and in efficiency. The purpose of this paper is to present some of reliability prediction methodologies that are applicable to machine tools. Especially ATC (Automatic Tool Changer) and Interface Card of PC-NC, which are core components of the machine tools, were chosen as the target of the reliability evaluation and analysis. The results of this research has shown the failure rate, MTBF(Mean Time Between Failure), and reliability for those components. It is expected that proposed methodologies will be applicable to evaluation of reliability for other industrial products.