Thermomechanical behavior of Al-Mg-Si alloys was studied to investigate the effect of microstructural features such as pre-existing substructure and distribution of particles on the deformation characteristics. The controlled compression tests were carried out to get the information on how the alloy responds to temperature, strain amount and strain rate. Then hot forging of Al-Mg-Si alloys carried out and analyzed by the comparison with the compression tests. Microstructural features after forging were discussed in terms of the thermomechanical response of Al-Mg-Si alloys. As already well mentioned, we found that the deformation of Al-Mg-Si at the elevated temperature brought the recovered structure on most conditions. In a certain time, however, abnormally large grains were found as a result of deformation assisted grain growth, which means that hot forging of Al-Mg-Si alloys could lead to a undesirable microstructural variation and the consequent mechanical properties such as fatigue strength.