It is difficult to have the existing structural optimization using coupled field analysis from CFD to structure analysis when the structure is influenced of fluid. Therefore in an initial model of this study after doing parameter design from the background of shape using topology optimization. and it is making a approximation formula using by the CFD-structure coupled-field analysis and design of experiment. By using this result, we conducted multi-objective optimization. We could confirm efficiency of stochastic method applicable in the scene of structure reliability design to be needed multi-objective optimization. And we presented a way of design that could overcome the time and space restriction in structural design such as the butterfly valve with the less experiment.