The effect of soil-structure interaction becomes important in the design of civil structures such as long-span bridges, which are constructed in the site composed of soft soil. Many methodologies have been developed to account for the proper consideration of soil-structure interaction effect. However, it is difficult to estimate soil-structure interaction effect accurately becaused of many uncertainties. This paper presents the results of study on soil-structure interaction and dynamic response of a long-span bridge designed in the site composed of soft soil. The effect of the soft soil was evaluated by the use of computer program SASSI and a long-span bridge structure was modeled by finite elements. Dynamic response characteristics of a long-span bridge considering soil-structure interaction wereinvestigated.