Hyperhidrosis of the palms and soles is a disorder characterized by excessive sweating that occurs in the hands and feet and that cause severe psychological, social and/or professional disability. The pathophysiological cause is still unknown but the condition is related to over-activity in the Sympathetic Nervous System. We experienced four young patients with hyperhidrosis of the palms and soles that was thought to be initiated by emotional distress, nervousness, stressful situation and anxiety. In the point of Differentiation of Syndrome, this subject was diagnosed as consumptive fever of the Heart and a weakness of the Spleen and damp heat, and was administrated with Yangshimtang-Gamibang. After treatment of herbal medicine and acupuncture, hyperhidrosis and other symptoms of patients were improved.