In this study, based on shaking table test results on a seismically isolated bridge model, an inelastic numerical model is refined by using Bouc-Wen model representing the hysteretic behavior of isolators. Seismic responses of isolated bridges are numerically investigated varying with relative stiffness ratio(RSR), which is a ratio of the effective stiffness of isolator to the lateral stiffness of bridge pier, From the results, it is found that an adequate range of relative stiffness ratio could be defined for seismic design of isolated bridges without considering the flexibility of piers.