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The Protective Effects of Isoflavone Extracted from Soybean Paste in Free Radical Initiator Treated Rats
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  • The Protective Effects of Isoflavone Extracted from Soybean Paste in Free Radical Initiator Treated Rats
  • The Protective Effects of Isoflavone Extracted from Soybean Paste in Free Radical Initiator Treated Rats
저자명
Nam. Hye-Young,Min. Sang-Gi,Shin. Ho-Chul,Kim. Hwi-Yool,Fukushima. Michihiro,Han. Kyu-Ho,Park. Woo-Jun,Choi. Kang-Duk,Lee. Chi-H
간행물명
Food science and biotechnology
권/호정보
2005년|14권 5호|pp.586-592 (7 pages)
발행정보
한국식품과학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
서지반출

기타언어초록

This study was performed to investigate the antioxidant effects of Korean soybean paste extracts (SPE) on 2,2-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced liver damage in rats. Thirty healthy Sprague Dawley rats were selected and divided into 5 groups. Isoflavone contents were measured using HPLC technique. The antioxidant activity was measured in the plasma and liver of the rats with the following results. Levels of isoflavone in fermented soy paste, red pepper paste and soy sauce were 28.9, 30.3 and $3.4;{mu}g/g$ for daidzein and 244.3, 187.7 and $6.1;{mu}g/g$ for genistein, respectively. The activities of glutamate oxaloacetic transaminase (GOT) and glutamate pyruvate transaminase (GPT) were significantly higher in the AAPH-treated group in the SPE-AAPH group (p<0.05). The thiobarbituric acid reactive substance (TBARS) production was significantly increased in the AAPH-treated liver tissue (P<0.05). Glutathione peroxidase (GPx), glutathione reductase (GR) and catalase in the liver were significantly (p<0.05) decreased by AAPH administration. The glutathione (GSH) concentration was higher in the SPE-treated (Ed- confirm) group than in the control and other groups (p<0.05). These results suggest that SPE led to increased anti oxidative activities against AAPH-induced peroxyl radical.