Purpose: To develop a substantive theory that represents caring experience from their the spouses perceived by hemodiialysis patients. Method: Grounded theory method guided the data collection and analysis. A purposeful sample of 15 hemodiialysis patients participated from April, 2005 to September, 2005. The data were collected through in-depth interviews. All interviews were audio taped and transcribed verbatim. Constant comparative analysis were performed simultaneously. Result: The core category on caring experience from their the spouses perceived by hemodialysis patients was identified "Re-establishment for life". The process was categorized into four stage, "Escaping", "Accepting", "Enduring", "Transcending". Conclusion: This study provides a framework for the development of individualized nursing intervention to care for the hemodialysis patients.