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Hepatoprotective effect of kasni against aflatoxin B1 induced hepatic damage in mice
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  • Hepatoprotective effect of kasni against aflatoxin B1 induced hepatic damage in mice
  • Hepatoprotective effect of kasni against aflatoxin B1 induced hepatic damage in mice
저자명
Naaz. Farah,Abdin. MZ,Javed. Saleem
간행물명
Oriental pharmacy and experimental medicine : OPEM
권/호정보
2006년|6권 3호|pp.196-201 (6 pages)
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경희한의학연구센터
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정기간행물|ENG|
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이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

The efficacy of alcoholic extract of Kasni (Cichorium intybus L.) to control hepatic damage induced by aflatoxin $B_1$ was explored in Swiss albino mice. Aflatoxin $B_1$ was administered orally to the mice with a daily dose of $66.6{mu}g/kg$ body weight till three months. A signifi-cant increased in thio barbituric acid reactive substances (TBARS) levels with concomitant reduction in enzymatic (glutathione-s-transferase, glutathione peroxidase, superoxide dismutase, and catalase) and nonenzymatic (reduced glutathione) antioxidants were shown in aflatoxin treated group of mice. However, there was a significant reduction in increased TBARS levels and elevation in enzymatic. and non enzymatic antioxidant levels in group of mice which received alcoholic extract of kasni (300 mg/kg bw / day) along with aflatoxin. Histopathological analysis of liver samples also confirmed the hepatoprotective effect of kasni extract. These results suggest that kasni shows hepatoprotective effect against aflatoxin $B_1$ induced hepatic damage in mice.