The results of this study suggest the use of a Back Propagation Network (BPN) algorithm for the detection of esophageal erosions or abnormalities - which are the important signs of esophagitis - in the analysis of the color and textural aspects of clinical images obtained by endoscopy. The authors have investigated the optimization of the learning condition by the number of neurons in the hidden layer within the structure of the neural network. By optimizing learning parameters, we learned and have validated esophageal erosion images and/or ulcers functioning as the critical diagnostic criteria for esophagitis and associated abnormalities. Validation was established by using twenty clinical images. The success rates for detection of esophagitis during calibration and during validation were 97.91% and 96.83%, respectively.