Purpose: This research has been conducted in order to confirm the major factors that prediction organizational commitment in registered nurses. Method: The subjects were 350 registered nurses from 3 hospitals in Seoul. The sample for data collection consisted of 329 useable questionnaires (94% overall return rate) for 2 weeks. The Instrument tools utilized in this study were organizational commitment scale, empowerment scale, job stress scale and job satisfaction scale and thoroughly modified to verify validity and reliability. The collected data have been analyzed using SPSS 11.0 program. Three outliers which were bigger than 3 in absolute value were found, so after taking them off, Multiple Regression was used for further analysis. Result: The major factors that prediction organizational commitment in registered nurses were job satisfaction, empowerment, age and unit experience, which explained 51.9% of organizational commitment. Conclusion: It has been confirmed that the regression equation model of this research may serve as a organizational commitment prediction factors in Registered Nurses.