The fatigue strength of the welds is affected by such factors as the weld geometry, microstructures, tensile properties and residual stresses caused by fabrication. It is very important to evaluate the structural integrity of the welds in nuclear power plant because the weldment undergoes the most of damage and failure mechanisms. In this study, the fatigue assessments for a reactor vessel outlet nozzle with the weldment to the piping system are performed considering the welding residual stresses as well as the effect of local brittle zone in the vicinity of the weld fusion line. The analytical approaches employed are the microstructure and mechanical properties prediction by semi-analytical method, the thermal and stress analysis including the welding residual stress analysis by finite element method, the fatigue life assessment by following the ASME Code rules. The calculated results of cumulative usage factors(CUF) are compared for cases of the elastic and elasto-plastic analysis, and with or without residual stress and local brittle zone effects, respectively. Finally, the fatigue life of reactor vessel outlet nozzle weld is slightly affected by the local brittle zone and welding residual stresses.