The goal of this research is to develop and apply the generalized regression neural networks model(GRNNM) embedding genetic algorithm(GA) for the estimation and calculation of the pan evaporation(PE), which is missed or ungaged and of the alfalfa reference evapotranspiration ($ET_r$), which is not measured in South Korea. Since the observed data of the alfalfa 37. using Iysimeter have not been measured for a long time in South Korea, the Penman-Monteith(PM) method is used to estimate the observed alfalfa $ET_r$. In this research, we develop the COMBINE-GRNNM-GA(Type-1) model for the calculation of the optimal PE and the alfalfa $ET_r$. The suggested COMBINE-GRNNM-GA(Type-1) model is evaluated through training, testing, and reproduction processes. The COMBINE-GRNNM-GA(Type-1) model can evaluate the suggested climatic variables and also construct the reliable data for the PE and the alfalfa $ET_r$. We think that the constructive data could be used as the reference data for irrigation and drainage networks system in South Korea.