Objectives: This study was to investigate the level of xerostomia and depression in the elderly people and to determine the relationship between xerostomia and depression. Methods: The subjects were 238 subjects(86.5%), who were 65 years or older with mean age of 73.6 years. Data was collected using a self administrated questionnaire from September 14 to September 23, 2005. Perception of xerostomia was measured by questionnaire, and depression was measured using the 20-items CES-D. The data were analysed with t-test, one-way ANOVA, pearson correlation coefficient and multiple regression using the SPSS 12.0 Windows. Results: Regarding xerostomia, the subjects was a mean of 7.87 out of a maximum 12 points. The level of depression in the group of people 65 years or older was 21.51 out of a maximum 60 points. Xerostomia was positive related depression in this study. Perceived oral health and xerostomia had a significant impact on depression. Conclusion: Based on the findings, the perception of xerostomia is strongly associated with depression. These results suggest that oral health promotion should be considered various psychological factors related xerostomia in elders.