In this paper, we found that modification of the local flexibility (or local stiffness) of the 4 parts on which shock absorbers are mounted in the vehicle body has some influence the level of ride safety and comfort. Multi-body dynamic analysis considering the flexibility of the vehicle body is performed using MSC/ADAMS and MSC/NASTRAN. More concretely speaking, natural frequencies and mode shapes computed by MSC/NASTRAN are used as input data for multi-body dynamic analysis in MSC/ADAMS. It is confirmed that the ride comfort can be improved by appropriately changing the local stiffness of the vehicle body through several simulations using MSC/ADAMS.