The purpose of this study is to analyze spray and evaporation characteristics of DME fuel at the high pressure and temperature. For the numerical analysis of dimethyl ether(DME) fuel spray characteristics, hybrid breakup model was applied to the DME spray and its breakup process. In order to obtain experimental results for comparison with the predicted ones, the visualization of the spray evolution process was executed by using a Nd:YAG laser. Also, the numerical investigation was conducted by the two hybrid models for primary and secondary breakup of the DME spray. The primary breakup model was used the Kelvin-Helmholtz(KH) breakup model. In the secondary breakup process, Rayleigh-Taylor(RT) and Drop Deformation Breakup(DDB) model was applied. The results of this study provide the macroscopic characteristics of the spray such as spray tip penetration and cone angle, and prediction accuracy of the two hybrid model.