This article presents a two-stage turbocharged heavy-duty diesel (HDD) engine designed to fulfil the US2007 anti-pollution directive. This directive imposes very restrictive limits on the NOx and particle emissions of HDD engines. In this work, the possibility of combining particle traps in the exhaust line to reduce soot emissions with very high EGR rates to reduce NOx emissions is considered. This new generation engine implements two-stage trubocharging in order to improve the bsfc when the engine is working on steady conditions as well as to optimize the engine transient response. After carrying out the tests, the results were analyzed and the engine settings were adjusted to maximise its behaviour and minimise pollutant emissions. NOx and soot emission peaks were also analyzed at engine transient conditions in order to keep them under certain levels, and thus maintain the overall pollutant emissions to a level that is as low as possible. In summary, a double-stage turbocharging configuration can greatly improve engine driveability (between 23% and 36% depending on engine speed), while reducing NOx emissions during transient evolution without increasing opacity peaks beyond the stated limits.