Rolling-sliding, cyclic contact of wheel and rail progressively alters the microstructure of the contacting steels, eventually leading to micro-scale crack initiation, wear and macro-scale crack growth in the railhead. Relating the microstructural changes to subsequent wear and cracking is being accomplished through modelling at three spatial scales: (i) bulk material (ii) multi-grain and (iii) sub-grain. The models incorporate detailed information from metallurgical examinations of used rails and tested rail material. The initial 2-dimensional models representing the rail material are being further developed into 3-dimensional models. Modelling is taking account of thermal effects, and traffic patterns to which the rails are exposed.