This study reflects the concept of risk-based design to present a systematic design means and a method to adjust regulations and standards towards a more reliable direction within the current law. In order to enhance the early design concentration and level in the part of safety design, a new Advanced Safety Analysis Table (ASAT) was developed to provide information on the systematized safety design element from the early design phase. Furthermore, a guideline was put forth about the selection of a safety device according to process trouble, on the basis of the ASAT. To apply the proposed ASAT and the selection method of a safety device according to process troubles, the ASAT was executed for the PGC (Process Gas Compressor) of the NCC (Naphtha Cracking Center), and the result of selecting the safety device was analyzed according to process trouble.