- 이오도늄 솔트 전구체를 이용한 새로운 방향족 화합물 플루오린-18 표지 기술
- ㆍ 저자명
- 문병석,이병철,김상은,Moon. Byung-Seok,Lee. Byung-Chul,Kim. Sang-Eun
- ㆍ 간행물명
- 핵의학 분자영상
- ㆍ 권/호정보
- 2009년|43권 1호|pp.1-9 (9 pages)
- ㆍ 발행정보
- 대한핵의학회
- ㆍ 파일정보
- 정기간행물| PDF텍스트
- ㆍ 주제분야
- 기타
As many new drug substances contained various aromatic rings and fluorine attached to an electron rich aromatic ring or on the meta-position, a strategy towards improvement in aromatic fluorination of these compounds is highly desirable. The introduction of fluorine-18 onto aromatic rings showed in the limited condition containing electron withdrawing group (EWG) on the para- or ortho-position to get reasonable radiochemical yield so far. No-carrier added (NCA) [$^{18}F$]fluoroarene syntheses by iodonium salts recently reported that has the potential to greatly increase the yield in systems or positions that normally not reactive enough to give sufficient yields in simple model reaction. This review describes the methodological approach towards effective aromatic fluorination by diaryliodonium salts and future prospects in an application of novel PET radiotracer.