One thing to note in cyclone operation and design is to minimize the pressure drop with the enhancement of the efficiency of dust collection. This can be facilitated by the detailed resolution of complex fluid flow occurring inside a cyclone. To this end, the main objective of this study was to obtain the detailed fluid dynamics by the development of a reliable computation method and thereby to figure out the physics of dust collection mechanism for more extreme environment caused by high temperature and pressure condition. First of all, the computer program developed was evaluated against experimental result. That is, the numerical calculation predicts well the data of experimental pressure drop as a function of flow rate for the elevated pressure and temperature condition employed in this study. The increase of pressure and temperature generally affects significantly the collection efficiency of fine particle but the effect of pressure and temperature appears contrary each other. Therefore, the decrease of collection efficiency caused by the high operating temperature mainly due to the decrease of gaseous density can be remedied by increase of operating pressure. After the evaluation of the program, a series of parametric investigations are performed in terms of major cyclone design or operating parameters such as tangential velocity and vortex finder diameter for dusts of a certain range of particle diameters, etc. As expected, tangential velocity plays the most important effect on the collection efficiency. And the efficiency was not affected significantly by the change of the length of vortex finder but the diameter of vortex finder plays an important role for the enhancement of collection efficiency.