A series of 6- or 7-methylchroman-2-carboxylic acid N-(substituted) phenylamides (2a-s, 3a-s) were synthesized. Their abilities to inhibit nuclear factor-${kappa}B$ (NF-${kappa}B$) activity were evaluated in lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. Compounds with substituents such as -H, $-CH_3$, and $-CH_3$ on the phenyl ring were poor inhibitors of NF-${kappa}B$. The most active NF-${kappa}B$ inhibitors contained 4-Cl (3s) and 4-OMe (3g) in the 7-methylchroman-2-carboxamide derivatives and 2-OH (2b) and 4-Cl (2s) in the 6-methylchroman-2-carboxamide derivatives ($IC_{50}$: $20.2-24.0;{mu}M$). These were slightly more potent than a reference compound, KL-1156 (1) ($IC_{50}$: $43.9;{mu}M$).