This paper deals with the main physical-chemical properties of ethanol-diesel blend and the effects of ethanol-diesel blends (up to 15% volume) on engine performance (full load torque vs. engine speed, BSEC vs. torque at 1400 r/min and 2300 r/min, and effect of start of injection angle) and emissions in ECE R49 tests (steady 13 points) using a 6.6 L inline 6-cylinder turbocharged direct injection diesel engine. The results show that an increase in ethanol fraction results in decreased viscosity of the blend fuel and very high distillation characteristics in the low temperature range. Solvents can improve the solubility of ethanol-diesel blends. The engine power was degraded proportional to the ethanol content (10% and 15%) due to the LHV (low heating value) of the blends. The higher latent heat of vaporization and lower CN (cetane number) of ethanol, which results from the steady state emissions of CO, HC, and SOF (soluble organic fraction), were much higher in the ECE R49 tests at low loads. Soot (solid mass) emissions were improved. The particulate matter emissions were significantly increased with higher blend volumes, and NOx emissions slightly increased with higher ethanol volumes. By increasing the injection angle properly, the performance parameters of the diesel engine were improved, but NOx emissions were deteriorated slightly.