Purpose: This study was intended to examine an effect of taping therapy for adults suffering from ankle pain. Method: A non-equivalent control group pretest-posttest design was used for the study. An experimental group had 32 subjects and a control group 23 subjects. Subjects from the experimental group were taped for 24 hours and thereafter their range of motion [ROM], pain, and discomfort in the injured ankle were evaluated. SPSS Windows was used for data analysis. Result: The degree of ROM of the taped experimental subjects was greater compared to that of non-taped control subjects. The score of ankle pain of the taped subjects was lower than that of non-taped subjects. The score of ankle discomfort of the taped subjects was lower than that of non-taped subjects. Conclusion: This taping therapy can be used independently by nurses as an effective nursing intervention to decrease ankle pain and discomfort after the injury of ankle, which would contribute to expanding a realm of nursing.