In this Paper, We analyzed influence Factor to TPM Performance in medium and small enterprises by empirically. By Literature survey, We hypothesize education training and 5S influence to individual improvement, independence maintenance, planning and foresight, which also influence to flexibility, total equipment performance, quality, which finally influence to lower cost, delivery date. To analyze empirically, we survey questionnaire in medium and small enterprises being below 300 people. From statistical analysis, 7 hypotheses are rejected, which is different existing research. This is analyzed that reflect actuality that medium and small enterprises is different from large enterprises. We expect that result of this treatise does concentration effort in important factor to get TPM performance in medium and small enterprises.