Purpose: The purpose of this study was to identify the health promotion, stress and the quality of life and relationship between those factors in patients with genital neoplasms. Method: Data of 151 subjects with genital neoplasms were collected from August 15 to October 12, 2009 at out-patient clinic in one general hospital in Daegu. Results: The mean score of health promotion of the subjects was 1.49 (${pm}0.53$), stress of gynecologic cancer was 1.36 (${pm}0.76$) and the quality of life of the subjects was 2.38 (${pm}0.59$). There was a negative correlation between the quality of life and stress (r=-.482, p<.001), and positive correlation between the quality of life and health promotion (r=.442, p<.001) in the subjects. Conclusion: This study showed correlations between the health promotion, stress and the quality of life of patients with genital neoplasms. The quality of life of the patients with genital neoplasms was low when their stress was high. In contrast, their quality of life was high when the score of health promotion was high. Considering the research findings, it is necessary to develop a health promotion program for patients with genital neoplasms to strengthen their health promotion behaviors.