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A Potential Inhibitor of Rat Aortic Vascular Smooth Muscle Cell Proliferation from the Pollen of Typha angustata
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  • A Potential Inhibitor of Rat Aortic Vascular Smooth Muscle Cell Proliferation from the Pollen of Typha angustata
  • A Potential Inhibitor of Rat Aortic Vascular Smooth Muscle Cell Proliferation from the Pollen of Typha angustata
저자명
Nhiem. Nguyen Xuan,Kiem. Phan Van,Minh. Chau Van,Lee. Jung-Jin,Ku. Ja-Hyeong,Myung. Chang-Seon,Kim. Young-Ho
간행물명
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
권/호정보
2010년|33권 12호|pp.1937-1942 (6 pages)
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대한약학회
파일정보
정기간행물|ENG|
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기타
이 논문은 한국과학기술정보연구원과 논문 연계를 통해 무료로 제공되는 원문입니다.
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기타언어초록

By various chromatographic methods, three flavonoids, (2S)-naringenin (1), isorhamnetin 3-O-(2-O-${alpha}$-L-rhamnopyranosyl) ${eta}$-D-glucopyranoside (2), typhaneoside (3), and two sterol glycosides, ${eta}$-sitosterol-3-O-(6-octadecanoyl) ${eta}$-D-glucopyranoside (4) and ${eta}$-sitosterol-3-O-(6-octadeca-9Z,12Z-dienoyl) ${eta}$-D-glucopyranoside (5), were isolated from the pollen of Typha angustata. Their structures were determined on the basis of spectroscopic analyses. The flavonoids (1 - 3) were evaluated for their effects on the viability and proliferation of rat aortic smooth muscle cells. (2S)-naringenin (1) significantly inhibited cell proliferation in a dose-dependent manner without cytotoxic at concentrations of 30, and 50 ${mu}M$; it reduced the number of cells following PDGF-BB treatment to $1.83{pm}0.30{ imes}10^4$ and $2.20{pm}0.60{ imes}10^4$ cells/well, respectively. These findings suggest that (2S)-naringenin has antiproliferative effects on aortic smooth muscle cells.