This experimental study was designed to investigate the inhibitory effects of hot water extract of Yukeuigambi-tang (YEGT) on high-fat diet-induced obesity and hyperlipidemia in C57BL/6 mice. Animals were divided into normal, control, YEGT(sample A 3.8 g/kg, and sample B 7.6 g/kg) treated group. Obesity with hyperlipidemia was induced by high fat diet treatment for 6 weeks. YEGT was given to the animals by oral gavage. The effect of YEGT on the body weight change, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, and leptin levels in serum were evaluated. In respect to the body weight change, sample B significantly reduced body weight compared with control group in the 6th weeks. In the total cholesterol, triglyceride, and leptin level, sample B significantly reduced all of them compared with control group; sample A significantly reduced triglyceride and leptin levels compared with control group. The above results suggest that YEGT is effective to prevention and treatment of obesity and hyperlipidemia.