This paper proposes the efficiency optimization control of interior permanent magnet synchronous motor(IPMSM) drive using series connected-fuzzy neural network PI(SC-FNPI) controller. The PI controller is generally used to control IPMSM drive in industrial field. However, the PI controller has problem which is falling control performance about parameter variation such as command speed, load torque and inertia due to fixed gain of PI controller. Therefore, to improve performance of PI controller, this paper proposes SC-FNPI controller adjusted input of PI controller by FNN controller according to operating conditions. Also, this paper proposes efficiency optimization control which is improving efficiency with minimize loss. The SC-FNPI controller proposed in this paper is compared control performance with conventional FNN and PI controller about command speed, load torque and inertia variation. And the efficiency optimization control is compared with $i_d=0$ control about loss and efficiency. The SC-FNPI controller proposed in this paper shows more excellent control performance for rising time, overshoot and steady-state error. Also efficiency optimization control is increased efficiency by reducing loss.