Recently, the demands of the large scale machine tools gradually increase to machine the large parts, such as large scale crankshaft, yaw and pitch bearings for the wind power generator and the vehicle or aircraft components. But the high technology is necessary in order to develop the huge machine tools. Furthermore, the global market of it has been monopolized by a few companies. So, we need to develop the large scale machine tools and study its core technology to rush into the increasing market. In this study, we carried out the researches for the important core technology of a multi-tasking, machine tool; a large scale 5-axis machine tool of gantry type for multi-task machining. This study is focused on the design of large size gantry type multi-axis machine. In the case of large size of machine the cross rail deflection in the X-axis is significant. To reduce the deflection due to the eccentric spindle head, a special hollow type design in the cross rail with outside ram is adapted in this study. Also, the Zig-Zag motion in the Y-axis is inevitable with the gantry geometry, which is by the un-balancing, different motion at the left and the right columns moving. We tried to reduce the influence of Zig-Zag motion using FEM with different loading conditions at the left and the right side column.