The titanate nanotube (TNT) was hydrothermally synthesized in 10 M NaOH aqueous solution at $150^{circ}C$ for 72 h. Titanate nanotube with high surface area (292 $m^2$/g) is a good candidate as a support for catalytic reaction or organic synthesis. Palladium nanoparticles with an average size of $ca$. 3 nm were well dispersed onto the surface of TNT nanotubes. Palladium loaded catalyst with high surface area shows a highly efficient ${alpha}$ alkylation of ketones with primary alcohols.