Objectives: The purpose of this study was to identify occupational stress and to determine level of depression of school nurses and to identify factors that influence depression. Methods: A cross-sectional design was employed in this study. Participants included 146 school nurses from D city. Data collection was conducted on January 17-21, 2011, using self-administered questionnaires. The SPSS/WIN 11.5 was used in performance of data analysis. Results: Significant differences in occupational stress were observed according to age, occupation and perceived mental health status, and in depression according to marital status, perceived mental health status and physical disease. Depression showed significant positive correlation with occupational stress (r=.35, p<.001). In regression analysis, occupational stress and physical health state were found to be the cause of depression in 17% of subject. Conclusion: Findings of this study allow for a comprehensive understanding of occupational stress and level of depression of school nurses in Korea. Further study using a larger random sample and various variables is needed.