In this study the real situation of apartment house in seoul is reproduced with multi-zone modeling program contam2.4. This model include immune building system(disinfection system) which is consist of dilution, Filter Technology and UVGI(ultra violet germicidal irrdiation). In this study experiments design method used for estimating interaction of HRV air change rate, UVGI air change rate and UVGI grade. Result show that HRV air change rate and UVGI air change rate is most influence factor for remove rate. also Interaction of HRV air change rate and UVGI air change rate is ost influence factor for remove rate.