The use of a concrete track is gradually growing in urban and high-speed railways in many part of the world. The resilient pad, which is essentially when concrete tracks are used, plays the important role of relieving the impact caused by train loads. The simple fatigue test[1] to estimate the variable stiffness of resilient pads is usually performed, but it differs depending on the practical conditions of different railways. In this study, the static stiffness levels of used resilient pads according to passing tonnages levels were measured in laboratory tests. Also, the simple fatigue test and the multi-stress accelerated degradation test for new resilient pads were performed in a laboratory. The static stiffness of the used pad was compared with the results of tests of usage times and cycles. The results of the comparison showed that the variable static stiffness levels of the used pad were similar to results of the multi-stress accelerated degradation test considering the fatigue and heat load. With a T-NT equation related to the degree of the multi-stress accelerated degradation, a model of multi-stress accelerated degradation for a resilient pad was devised. It was found through this effort that the total acceleration factor was approximately 2.62. Finally, this study proposes an equation for a multi-stress accelerated degradation model for polyurethane resilient pads.