Objective : Printed in early Chosun dynasty Hyangyakjipseongbang quoted several medical books that were published at that time. Yuyaoyuanfang was printed in Yuan dynasty, China and imported to Chosun dynasty. However, Yuyaoyuanfang was vanished in history and another Yuyaoyuanfang, which is now-exist[Guisixinkan-Yuyaoyuanfang], was printed in Japan. In Hyangyakjipseongbang, Yuyaoyuanfang are mentioned 31 times but Yuyaoyuanfang quoteded in Hyangyakjipseongbang is quite different from Guisixinkan-Yuyaoyuanfang. Therefore, we had interests of those differences and tried to find out them in article. Method : We use the method of comparing quotations of Yuyaoyuanfang in Hyangyakjipseongbang with Guisixinkan-Yuyaoyuanfang. Result : 4 of 31 prescriptions of Yuyaoyuanfang quoteded in Hyangyakjipseongbang does not exist in Guisixinkan-Yuyaoyuanfang and several parts such as symtoms, herbs, taking methods of prescriptions are different from each other. Conclusion : Hyangyakjipseongbang prove the fact that Guisixinkan-Yuyaoyuanfang is not original form of Yuyaoyuanfang.