Recent advanced IT made layout design fast and accurate by using algorithms. Layout design should be determined by considering the position of equipment with satisfying various space constraints and its component works with optimum performance. Especially, engine room layout design is performed with mother ship data, theoretical optimal solution, design requirements and several design constraints in initial design stage. Piping design is affected by position of equipment seriously. Piping design depends on experience of designer. And also piping designer should consider correlation of equipment and efficiency of space. In this study, space evaluation method has been used to evaluate efficiency of space. And also this study suggested object function for optimal piping route, Average Reservation Index(ARI), Estimated Piping Productivity(EPP) and with modified space evaluation method. In this study, optimum pipe routing system has been developed to reflect automated piping route with space efficiency and experience of piping designer. Engine room is applied to the design of the piping in order to confirm validity of the developed system.